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Drug Class and Mechanism - Fexofenadine is an oral, "second generation" antihistamine that is used to treat the signs and symptoms of allergy that are due to histamine.
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Drug Class and Mechanism - Fexofenadine is an oral, "second generation" antihistamine that is used to treat the signs and symptoms of allergy that are due to histamine.
It is similar to the other second generation antihistamines loratadine (Claritin), cetirizine (Zyrtec) and azelastine (Astelin). Histamine is a chemical that is responsible for many of the signs and symptoms of allergic reactions, for example, swelling of the lining of the nose, sneezing, and itchy eyes.
Histamine is released from histamine-storing cells (mast cells) and then attaches to other cells that have receptors for histamine. The attachment of the histamine to the receptors causes the cell to be "activated," releasing other chemicals that produce the effects that we associate with allergy, e.g., sneezing.
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